Highway 64 is a local route. You can end up with school buses and farm equipment. It also has several low overpasses but I think they are further east. Maybe closer to Mocksville.

here is a good alternate route. As several have already mentioned, I-40

Directions from Knoxville, T.N.:
I-40 East to Exit 27. Take Hwy 19A and 23 to Sylva. In Sylva, take Hwy 107 South to Cashiers. Turn left at the stoplight in Cashiers on Hwy 64. Continue approximately 12 miles to Lake Toxaway.