Kim, There is no downside to changing it, but I doubt if it will have an impact. If no codes are showing up then I suspect there is something external to DDEC that is opening the circuit.
What I cannot yet figure out is how the Jake plays into this. Does your Jake function when the cruise is engaged? On my first coach the Jake was disabled once the cruise was engaged. Your description and the wiring diagrams makes it sound like the Jake does continue to function. If that is the case the fault is likely relating to connections or components between the cruise switches and the Jake. That is solely a guess and since I know diddly about this it could be all wrong.
The thing to focus on would be the components that disengage the cruise, such as brake lights, the disengage switch, the cruise power switch, and anything within that range of items. It still sounds like something is loose and is intermittently opening the circuit.