There are three things that will destroy the mileage. Going fast, towing, and hilly terrain.
I only reset the Pro Driver with oil changes so the mileage I show doesn't reflect any special circumstance, but my driving under most conditions. We rarely go anywhere without our H2, I set the cruise to show 63 on the Pro Driver which shows 65 on the GPS and the speedometer. Hills are what comes with our trip, with some trips far worse than others.
Here is a photo of my Pro Driver taken about a year ago just prior to an oil change. My current Pro Driver shows about 1/2 MPG less which I attribute to a lot of driving in the mountains, and I can't confirm it, but I think the fuel is affecting my mileage.