Tuga,
A 22 can be fun to plink around with, and surely is cheap to shoot, but I would not depend on it to save my life.
At a minimum, a personal defense hand gun needs to be a .38 calibre.
There are several high quality guns chambered for .38 special or .380 auto.
Perhaps you should visit a range where you can try out several guns. Try a revolver vs an auto and see which feels more accurate to you. Try different calibres and see how they feel.